Future Therapeutic Approaches for Inflammatory Bowel Diseases
نویسندگان
چکیده
منابع مشابه
Future therapeutic approaches for inflammatory bowel diseases.
In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic and genetic biomarkers to personalize medicine. We attempt to reconcile past ...
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Our understanding of the etiology and pathogenesis of IBD has improved extensively over the past years. At the center of the pathogenesis seems to be an excessive pro-inflammatory immune reaction towards normal intestinal flora. The different factors involved in this concept will form the focus of this review. The initial phase of antigen processing and presentation can be influenced by either ...
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Inflammatory bowel disease is the second most common chronic inflammatory disorder after rheumatoid arthritis [1]. While the prevalence of Crohn’s disease has continued to rise over the last four decades, the prevalence of ulcerative colitis seems to remain relatively stable. The etiology of IBD is multi-factorial, consisting of a mixture of genetic and environmental factors that may serve as a...
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IBD ETIOLOGY AND PATHOGENESIS Infl ammatory bowel disease (IBD) is a collection of disorders characterized by idiopathic infl ammation of the gastrointestinal tract. Although primarily classifi ed as either ulcerative colitis (UC) or Crohn’s disease (CD), the presentation of IBD can vary in terms of clinical symptoms, including location of disease involvement, disease severity, age at diagnosis...
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In this review, the evidence to support the multifactorial and polygenic nature of the disease is briefly described. The past of genetics of inflammatory bowel disease (IBD) is characterized by unfulfilled promises and is now closed with a new vision and a new promise coming from a genetic epidemiology approach. The genome-wide screening has led to the first gene of IBD and has given a new insi...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2011
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2011.02.014